〖原著論文〗

(49) Novel Ridaifen-B Structure Analog Indces Apoptosis and Autophagy Depending on Pyrrolidine Side Chain
    T. Iwasawa, T. Shinomiya, N. Ota, N. Shibata, K. Nakata, I. Shiina, Y. Nagahara
    Biological Pharmaceutical Bulltin 2019, 42, 401–410. [Link]

(48) Reformatsky Reagent Promoted Acetylation of Primary and Secondary Aliphatic Alcohols Using Ethyl Acatate as an
   Acetyl Donor
    R. Fujihara, K. Nakata
    ChemistrySelect 2019, 4, 75–77. [Link]

    (47)

(47)
  Chiral-Auxiliary-Controlled Diastereoconvergent Benzamidation Reactions of Diastereomixtures of Diarylmethanols
   with Benzamide Catalyzed by SnBr4
    R. Kubo, K. Nakata
    Asian Journal of Organic Chemistry 2019, 8, 119–122. [Link]

    (48)

(46)  Stereoconvergent Chiral Inductive Diastereodivergent Sulfonamidation of Diastereomixtures of Diarylmethanols with
   Sulfonylamine Catalyzed by Lewis Acids
    H. Yamamoto, K. Nakata
    Organic Letters 2018, 20, 7057–7061. [Link]

    (46)

(45)
  Chiral Inductive Diastereoconvergent Allylation Reactions of Allyltrimethylsilane and Diastereomixtures of
   Diarylmethanols Catalyzed by FeCl3
    R. Fujihara, K. Nakata
    European Journal of Organic Chemistry 2018, 6566–6573. [Link]

    (45)

(44)
  Kinetic Resolution of Racemic 2-Hydroxyamides Using a Diphenylacetyl Component as an Acyl Source and a Chiral
   Acyl-Transfer Catalyst
    T. Murata, T. Kawanishi, A. Sekiguchi, R. Ishikawa, K. Ono, K. Nakata, I. Shiina
    Molecules 2018, 23, 2003. [Link]

    (44)

(43)
  Silylative Kinetic Resolution of Racemic 1-Indanol Derivatives Catalyzed by Chiral Guanidine
    S. Yoshimatsu, A. Yamada, K. Nakata
    Journal of Organic Chemistry 2018, 83, 452–458. [Link]

    (43)

(42)
  Chiral Inductive Diastereoconvergent Friedel–Crafts Alkylation Reaction of Diastereomixtures of Diarylmethanols with
   2-Naphthol Derivatives Catalyzed by SnBr4
    N. Suzuki, K. Nakata
    European Journal of Organic Chemistry 2017, 7075–7086. [Link]

    (42)

(41)
  Acylative Kinetic Resolution of Racemic Aromatic β-Hydroxy Esters Catalyzed by Chiral Nucleophilic
    N-(1-Arylethyl)benzoguanidines
    A. Yamada, K. Nakata, I. Shiina
    Tetrahedron: Asymmetry 2017, 28, 516–521. [Link]

    (41)

(40)
  Chemoselective N-Acetylation of Primary Aliphatic Amines Promoted by Pivalic Acid or Acetic Acid Using Ethyl
    Acetate as an Acetyl Donor
    T. Yoshida, S. Kawamura, K. Nakata
    Tetrahedron Letters 2017, 58, 1181–1184. [Link]

   (40)

(39)
  Kinetic Resolution of Racemic 2-Hydroxyacetals by the Asymmetric Esterification Using Mixed Anhydride Protocal
    K. Nakata, E. Tokumaru, T. Saitoh, T. Nakahara, K. Ono, T. Murata, I. Shiina
    Heterocycles 2017, 95, 277–289. [Link]

   (38)

(38)  (R)-(+)-N-Methylbenzoguanidine ((R)-NMBG) Catalyzed Acylative Kinetic Resolution of Racemic 3-Hydroxy-3-aryl-
    propanoates
    A. Yamada, K. Nakata
    Tetrahedron Letters 2016, 57, 4697–4701. [Link]

    (38)

(37)  SnBr4-Promoted Friedel–Crafts Type Dehydrative Alkylation Reaction of Diarylmethanols with 2-Naphthol Derivatives
    N. Suzuki, S. Tsuchihashi, K. Nakata
    Tetrahedron Letters 2016, 57, 1456–1459. [Link]    

   (37)

(36)
  InCl3-Promoted Intramolecular Decarboxylative Etherification of Benzylic Carbonates
    T. Tokumaru, K. Nakata
    Tetrahedron Letters 2015, 56, 2336–2339. [Link]

    00-Graphical abstract

(35)  Acceleration of CuI-Catalyzed Coupling Reaction of Alkyl Halides with Aryl Grignard Reagents Using Lithium Chloride
    K. Nakata, C. Feng, T. Tojo, Y. Kobayashi
    Tetrahedron Letters 2014, 55, 5774–5777.

(34)  A Novel Tamoxifen Derivatives, Ridaifen-F, is a Nonpeptidic Small-Molecular Inhibitor
   M. Hasegawa, Y. Yasuda, M. Tanaka, K. Nakata, E. Umeda, Y. Wang, C. Watanabe, S. Uetake, T. Kunoh, M. Shionyu,
   R. Sasaki, I. Shiina, T. Mizukami
    European Journal of Medicinal Chemistry 2014, 70, 290–305.

(33)  An Enantiodivergent Synthesis of (+)- and (–)-Centrolobines by Asymmetric Esterification Catalyzed by (R)-(+)-N-
    Methylbenzoguanidine ((R)-NMBG)
    K. Nakata, T. Tokumaru, H. Iwamoto, Y. Nishigaichi, I. Shiina
    Asian Journal of Organic Chemistry 2013, 2, 920–922. [Link]
    Asian Journal of Organic Chemistry 2014, 3, 9.
    Special Issue: 40 Years of the Mukaiyama Aldol Reaction, 1973–2013
    [Highlighted in ChemistryViews] [Link]
    [Most Accessed Article in Oct and Nov/2013]
    (33)
 
(32) Novel Tamoxifen Derivative Ridaifen-B Induces Bcl-2 Independent Autophagy without Estrogen Receptor Involvement
   Y. Nagahara, M. Takeyoshi, S. Sakemoto, I. Shiina, K. Nakata, K. Fujimori, Y. Wang, E. Umeda, C. Watanabe,
   S. Uetake, T. Yamori, S. Dan, Y. Yoshimi, T. Shiomiya, M. Ikekita
   Biochemical and Biophysical Research Communications 2013, 435, 657–663.

(31) Kinetic Resolution of Racemic 2-Hydroxy-γ-butyrolactones by Asymmetric Esterification Using Diphenylacetic Acid with
   Pivalic Anhydride and a Chiral Acyl-Transfer Catalyst
   K. Nakata, K. Gotoh, K. Ono, K. Futami, I. Shiina
   Organic Letters 2013, 15, 1170–1173.
   
(30)
 Kinetic Resolution of Racemic Secondary Benzylic Alcohols by the Enantioselective Esterification of Using Pyridine-3-
   carboxylic Anhydride (3-PCA) with Chiral Acyl-Transfer Catalysts
   I. Shiina, K. Nakata, K. Ono, T. Mukaiyama
   Helvetica Chimica Acta 2012, 95, 1891-1911.

(29)
 A New Method for Production of Chiral 2-Aryloxypropanoic Acids Using Effective Kinetic Resolution of Racemic 2-
   Aryloxycarboxylic Acids
   A. Tengeigi, K. Nakata, K. Ono, I. Shiina
   Heterocycles 2012, 86, 1227-1252.

(28)
 Non-enzymatic Dynamic Kinetic Resolution of Racemic α-Arylalkanoic Acids: An Advanced Asymmetric Synthesis of
   Chiral Nonsteroidal Anti-inflammatory Drugs (NSAIDs)
   I. Shiina, K. Ono, K. Nakata
   Catalysis – Science & Technology 2012, 2, 2200–2205.
   [Cover Feature Article] 
   [Selected as a Hot Article]
   [Most Read Article in Oct/2012]

(27) A Convenient Method for the Kinetic Resolution of Racemic 2-Hydroxyalkanoates Using Diphenylacetic Anhydride
   (DPHAA) and a Cchiral Acyl-Transfer Catalyst
   K. Nakata, A. Sekiguchi, I. Shiina
   Tetrahedron: Asymmetry 2011, 22, 1610–1619.

(26)
 Synthesis of an Advanced Intermediate toward the hNK-1 Antagonist with the Cyclopentane Core
   K. Nakata, Y. Kiyotsuka, T. Kitazume, Y. Kobayashi
   Synlett 2011, 19, 2872–2874.

(25)
 (R)-(+)-N-Methylbenzoguanidine ((R)-NMBG) Catalyzed Kinetic Resolution of Racemic Secondary Benzylic Alcohols
   with Free Carboxylic Acids by Asymmetric Esterification
   K. Nakata, I. Shiina
   Organic & Biomolecular Chemistry 2011, 9, 7092–7096.

(24)
 Ridaifen-G Induced Caspase-independent Atypical Cell Death
   A. Anlifeire, M. Hatori, A. Morita, I. Shiina, K. Nakata, Y. Tosaki, Y.-W. Wang, M. Ikekita, G. Li
   Chinese Journal of Cell Biology 2011, 33, 635–644.

(23)
 Kinetic Resolution of the Racemic 1-(Aryloxazol-2-yl)carbinols with Achiral Carboxylic Acids by Asymmetric
   Esterification: A New Method for the Preparing Chiral 1,2-Amino Alcohols
   K. Nakata, K. Ono, I. Shiina
   Heterocycles 2011, 82, 1171–1180.

(22)
 Kintic Resolution of the Racemic 1-Heteroarylalkanols by the Asymmetric Esterification Using Diphenylacetic Acid with
   Pivalic Anhydride and a Chiral Acyl-Transfer Catalyst
   I. Shiina, K. Ono, K. Nakata
   Chemistry Letters 2011, 40, 147–149.

(21)
 Synthesis of Lasofoxifen, Nafoxidine and Their Positional Isomers via the Novel Three-Component Coupling Reaction
   K. Nakata, Y. Sano, I. Shiina
   Molecules 2010, 15, 6773–6794.

(20)
 An Effective Kinetic Resolution of Racemic α-Arylpropanoic Acids, α-Arylbutanoic Acids, and β-Substituted-α-
   arylpropanoic Acids with Bis(9-phenanthryl)methanol as a New Achiral Nucleophile in the Asymmetric Esterification
   Using Carboxylic Anhydrides and the Acyl-transfer Catalyst
   K. Nakata, Y. Onda, K. Ono, I. Shiina
   Tetrahedron Letters 2010, 51, 5666–5669.

(19)
 Kinetic Resolution of Racemic α-Arylalkanoic Acids with Achral Alcohols via the Asymmetric Esterification Using
   Carboxylic Anhydrides and Acyl-Tansfer Catalysts
   I. Shiina, K. Nakata, K. Ono, Y. Onda, M. Itagaki
   Journal of the American Chemical Society 2010, 132, 11629–11641.
   [Highlighted in Synfacts 2010, 11, 1304]
   [Highlighted in Organic Chemistry Highlights 2011 in July 18]

(18) Kinetic Resolution of the Racemic 2-Hydroxyalkanoates Using the Enantioselective Mixed-Anhydride Method with
   Pivalic Anhydride and a Chiral Acyl-Transfer Catalyst
   I. Shiina, K. Nakata, K. Ono, M. Sugimoto, A. Sekiguchi
   Chemistry – A European Journal 2010, 16, 167–172.

(17)
 An Effective Kinetic Resolution of Racemic Secondary Benzylic Alcohols Using 3-Pyridinecarboxylic Anhydride and a
   Chiral Acyl-Transfer Catalyst in the Absence of Tertiary Amine
   K. Nakata, I. Shiina
   Heterocycles 2010, 80, 169–175.

(16)
 Allylic Substitution of 4-Cyclopentene-1,3-diol Monoacetate with Copper Reagents Derived from Functionalized Aryl
   Grignard Reagents
   Y. Kobayashi, Y. Tani, K. Nakata, Y. Kaneko
   Synlett 2010, 2, 325–328.

(15)
 2,2-Disubstituted Propionic Anhydrides: Effective Coupling Reagents for the Kinetic Resolution of Secondary Benzylic
   Alcohols Using BTM
   I. Shiina, K. Nakata, M. Sugimoto, Y. Onda, T. Iizumi, K. Ono
   Heterocycles 2009, 77, 801–810.

(14)
 Kinetic Resolution of Racemic Carboxylic Acids Using Achiral Alcohols by the Promotion of Benzoic Anhydrides and
   Tetramisole Derivatives: An Application to Produce Chiral Nonsteroidal Anti-inflammatory Drugs and Their Esters
   I. Shiina, K. Nakata, Y. Onda
   European Journal of Organic Chemistry 2008, 5887–5890.
   [Most Accessed Article in Nov/2008]

(13) Realization of Anti-SN2’ Selective Allylation of 4-Cyclopentene-1,3-diol Monoester with Aryl- and Alkenyl Zinc Reagents
   K. Nakata, Y. Kiyotsuka, T. Kitazume, Y. Kobayashi
   Organic Letters 2008, 10, 1345–1348.

(12)
 Induction of Mitochondria-Involved Apoptosis in Estrogen Receptor Negative Cells by a Novel Tamoxifen Derivative,
   Ridaifen B
   Y. Nagahara, I. Shiina, K. Nakata, A. Sasaki, T. Miyamoto, M. Ikekita
   Cancer Science 2008, 99, 608–614.

(11)
 Synthesis and Pharmacological Evaluation of the Novel pseudo-Symmetrical Tamoxifen Derivatives as Anti-tumor
   Agents
   I. Shiina, Y. Sano, K. Nakata, T. Kikuchi, A. Saski, M. Ikekita, Y. Nagahara, Y. Hasome, T. Yamori, K. Yamazaki
   Biochemical Pharmacology 2008, 75, 1014–1026.

(10)
 4-(Dimethylamino)pyridine N-oxide (DMAPO): an Effective Nucleophilic Catalyst in the Peptide Coupling Reacion
   Using 2-Methyl-6-nitrobenzoic anhydride
   I. Shiina, H. Ushiyama, Y. Yamada, Y. Kawakita, K. Nakata
   Chemistry – An Asian Journal 2008, 3, 454–461.

(9)
  An Expeditious Synthesis of Tamoxifen, A Representative SERM (Selective Estrogen Receptor Modulator), via the
   Three-Component Coupling Reaction among Aromatic Aldehyde, Cinnamyltrimethylsilane and β-Chlorophenetole
   I. Shiina, Y. Sano, K. Nakata, M. Suzuki, T. Yokoyama, A. Sasaki, T. Orikasa, T. Miyamoto, M. Ikekita, Y. Nagahara,
   Y. Hasome
   Bioorganic & Medicinal Chemistry 2007, 15, 7599–7617.
   [Selected as a Top 25 Hottest Articles in Oct to Dec 2007]

(8)
  The First Asymmetric Esterification of Free Carboxylic Acids with Racemic Alcohols Using Benzoic Anhydrides and
   Tetramisole Derivatives: An Application to the Kinetic Resolution of Secondary Benzylic Alcohols
   I. Shiina, K. Nakata
   Tetrahedron Letters 2007, 48, 8314–8317.
   [Cover Feature Article]

(7)  Synthesis of the New pseudo-Symmetrical Tamoxifen Derivatives and Their Anti-tumor Activity
   I. Shiina, Y. Sano, K. Nakata, T. Kikuchi, A. Sasaki, M. Ikekita, Y. Hasome
   Bioorganic & Medicinal Chemistry Letters 2007, 17, 2421–2424.

(6)
 An Expeditious Synthesis of Lasofoxifene and Nafoxidine via the Novel Three-component Coupling Reaction
   Y. Sano, K. Nakata, T. Otoyama, S. Umeda, I. Shiina
   Chemistry Letters 2007, 36, 40–41.

(5)
 Aryl- and Alkenyllithium Preparations and Copper-Catalyzed Reaction between the Derived Magnesium Reagents and
   the Monoacetate of 4-Cyclopentene-1,3-diol
   K. Nakata, Y. Kobayashi
   Organic Letters 2005, 7, 1319–1322.

(4)
 New Reagent System for Attaining High Regio- and Stereoselectivities in Allylic Displacemet of 4-Cyclopentene-1,3-diol
   Monoacetate with Aryl- and Alkenylmagnesium Bromide
   Y. Kobayashi, K. Nakata, T. Ainai
   Organic Letters 2005, 2, 183–186.

(3)
  (Salen)ruthenium-Catalyzed Desymmetrization of Meso-Diols: Catalytic Aerobic Asymmetric Oxidation under Photo-
   Irradiation
   H. Shimizu, K. Nakata, T. Katsuki
   Chemistry Letters 2002, 1080–1081.

(2)
  Synthesis and Reactivity of (1-Fluorovinyl)phenyl Sulfoxide as a Dienophile
   T. Hanamto, K. Korekoda, K. Nakata, K. Hamada, Y. Koga, M. Kondo
   Journal of Fluorine Chemistry 2002, 118, 99–101.

(1)
  Asymmetric Epoxidation with a Photoactivated [Ru(salen)] Complex
   K. Nakata, T. Takeda, J. Mihara, T. Hamada, R. Irie, T. Katsuki
   Chemistry – A European Journal 2001, 7, 3776–3782.

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