原著論文

57.     Chiral Guanidine Catalyzed Acylative Kinetic Resolution of Racemic 2-Bromo-1-arylethanols
          E. Sawada, K. Nakata
          Chemistry Letters 202150, 371–373. https://doi.org/10.1246/cl.200786

56.     Lewis Acid-Catalyzed Nucleophilic Substitutions of Benzylic Alcohols with Sulfamides

          R. Oda, K. Nakata
          European Journal of Organic Chemistry 2021, 295–301. https://doi.org/10.1002/ejoc.202001320

55.     Chemodiergent Dehydrative Nucleophilic Substitutions of Diarylmethanols with 1-Phenyl-1
H-tetrazole-5-thiol
          Catalyzed by FeCl
3
          R. Oda, K. Nakata
          Asian Journal of Organic Chemistry 20209, 1234–1242. https://doi.org/10.1002/ajoc.202000301

54.     Kinetic Resolution of Racemic 2-Hydroxyketones by Asymmetric Esterification: Investigation of the Influence of the
          Co-base on the Selectivity

          T. Murata, K. Futami, R. Ishikawa, K. Ono, K. Nakata, I. Shiina
          Asian Journal of Organic Chemistry 20202, 202–205. https://doi.org/10.1002/ajoc.201900702

53.     Diastereoconvergent Dehydrative Nucleophilic Substitutions of Diastereomeric Diarylmethanols with 1,3-
          Dicarbonyls Catalyzed by SnBr
4
          R. Kubo, H. Yamamoto, K. Nakata
          European Journal of Organic Chemistry 2019, 7394–7398. https://doi.org/10.1002/ejoc.201901377

52.     Silylative Kinetic Resolutionof Racemic 2,2-Dialkyl 5-and 6-Membered Cyclic Benzylic Alcohol Derivatives

          Catalyzed by Chiral Guanidine, (R)-N-Methylbenzoguanidine
          S. Yoshimatsu, K. Nakata
          Advanced Synthesis & Catalysis 2019361, 4679–4684. https://doi.org/10.1002/adsc.201900761

51.     Acylative Kinetic Resolution of Racemic 2,2-Dimethyl Substituted Nitroaldol (Henry) Adducts Using a Chiral
          Guanidine Catalyst: (
R)-(+)-N-Methylbenzoguanidine ((R)-NMBG)
          T. Ichimura, R. Kishida, K. Nakata
          ChemistrySelect 20194, 9440–9443. https://doi.org/10.1002/slct.201803162

50.     Diastereoconergent Synthesis of Chiral Diarylmethyl Sulfones by Direct Sulfonylation of Diarylmethanols 
          Diastereomixtures with Sodium Sulfinates Catalyzed by SnBr2
          H. Yamamoto, K. Nakata
          European Journal of Organic Chemistry 2019, 4906–4910. https://doi.org/10.1002/ejoc.201900830

49.     Novel Ridaifen-B Structure Analog Induces Apoptosis and Autophagy Depending on Pyrrolidine Side Chain
          T. Iwasawa, T. Shinomiya, N. Ota, N. Shibata, K. Nakata, I. Shiina, Y. Nagahara
          Biological Pharmaceutical Bulltin 201942, 401–410. https://doi.org/10.1248/bpb.b18-00643

48.     Reformatsky Reagent Promoted Acetylation of Primary and Secondary Aliphatic Alcohols Using Ethyl Acatate as
          an
 Acetyl Donor
          R. Fujihara, K. Nakata
          ChemistrySelect 20194, 75–77. https://doi.org/10.1002/slct.201803162
          [Top Downloaded Article 2018–2019]

47.     Chiral-Auxiliary-Controlled Diastereoconvergent Benzamidation Reactions of Diastereomixtures of Diarylmethanols
         
with Benzamide Catalyzed by SnBr4
          R. Kubo, K. Nakata
          Asian Journal of Organic Chemistry 20198, 119–122. https://doi.org/10.1002/ajoc.201800635

46.     Stereoconvergent Chiral Inductive Diastereodivergent Sulfonamidation of Diastereomixtures of Diarylmethanols
          with Sulfonylamine Catalyzed by Lewis Acids
         H. Yamamoto, K. Nakata
         Organic Letters 2018, 20, 7057–7061. https://doi.org/10.1021/acs.orglett.8b03008

45.     Chiral Inductive Diastereoconvergent Allylation Reactions of Allyltrimethylsilane and Diastereomixtures of
          Diarylmethanols Catalyzed by FeCl
3
          R. Fujihara, K. Nakata
          European Journal of Organic Chemistry 2018, 6566–6573. https://doi.org/10.1002/ejoc.201801236

44.     Kinetic Resolution of Racemic 2-Hydroxyamides Using a Diphenylacetyl Component as an Acyl Source
          and a Chiral Acyl-Transfer Catalyst
          T. Murata, T. Kawanishi, A. Sekiguchi, R. Ishikawa, K. Ono, K. Nakata, I. Shiina
          Molecules 2018, 23, 2003. https://doi.org/10.3390/molecules23082003

43.     Silylative Kinetic Resolution of Racemic 1-Indanol Derivatives Catalyzed by Chiral Guanidine
          S. Yoshimatsu, A. Yamada, K. Nakata
          Journal of Organic Chemistry 2018, 83, 452–458. https://doi.org/10.1021/acs.joc.7b02493

42.     Chiral Inductive Diastereoconvergent Friedel–Crafts Alkylation Reaction of Diastereomixtures of
          Diarylmethanols with 2-Naphthol Derivatives Catalyzed by SnBr
4
          N. Suzuki, K. Nakata
          European Journal of Organic Chemistry 2017, 7075–7086. https://doi.org/10.1002/ejoc.201701280

41.     Acylative Kinetic Resolution of Racemic Aromatic β-Hydroxy Esters Catalyzed by Chiral Nucleophilic 
          N-(1-Arylethyl)benzoguanidines
          A. Yamada, K. Nakata, I. Shiina
          Tetrahedron: Asymmetry 2017, 28, 516–521. https://doi.org/10.1016/j.tetasy.2017.03.005

40.     Chemoselective 
N-Acetylation of Primary Aliphatic Amines Promoted by Pivalic Acid or Acetic Acid Using
          Ethyl Acetate as an Acetyl Donor
 
          T. Yoshida, S. Kawamura, K. Nakata
          Tetrahedron Letters 2017, 58, 1181–1184. https://doi.org/10.1016/j.tetlet.2017.02.015

39.     Kinetic Resolution of Racemic 2-Hydroxyacetals by the Asymmetric Esterification Using Mixed Anhydride
          Protocal
          K. Nakata, E. Tokumaru, T. Saitoh, T. Nakahara, K. Ono, T. Murata, I. Shiina
          Heterocycles 2017, 95, 277–289.

38.     (
R)-(+)-N-Methylbenzoguanidine ((R)-NMBG) Catalyzed Acylative Kinetic Resolution of Racemic
          3-Hydroxy-3-aryl-propanoates.
          A. Yamada, K. Nakata
          Tetrahedron Letters 2016, 57, 4697–4701. https://doi.org/10.1016/j.tetlet.2016.09.014

37.     SnBr
4-Promoted Friedel–Crafts Type Dehydrative Alkylation Reaction of Diarylmethanols with 2-Naphthol
          Derivatives
          N. Suzuki, S. Tsuchihashi, K. Nakata
          Tetrahedron Letters 2016, 57, 1456–1459. https://doi.org/10.1016/j.tetlet.2016.02.064

36.     InCl
3-Promoted Intramolecular Decarboxylative Etherification of Benzylic Carbonates
          T. Tokumaru, K. Nakata
          Tetrahedron Letters 2015, 56, 2336–2339. https://doi.org/10.1016/j.tetlet.2015.03.088

35.     Acceleration of CuI-Catalyzed Coupling Reaction of Alkyl Halides with Aryl Grignard Reagents Using
          Lithium Chloride
          K. Nakata, C. Feng, T. Tojo, Y. Kobayashi
          Tetrahedron Letters 2014, 55, 5774–5777.

34.     A Novel Tamoxifen Derivatives, Ridaifen-F, is a Nonpeptidic Small-Molecular Inhibitor
          M. Hasegawa, Y. Yasuda, M. Tanaka, K. Nakata, E. Umeda, Y. Wang, C. Watanabe, S. Uetake, T. Kunoh,
          M. Shionyu, R. Sasaki, I. Shiina, T. Mizukami
 
          European Journal of Medicinal Chemistry 
2014, 70, 290–305. 

33.     An Enantiodivergent Synthesis of (+)- and (–)-Centrolobines by Asymmetric Esterification Catalyzed by
          (
R)-(+)-N-Methylbenzoguanidine ((R)-NMBG) 
          K. Nakata, T. Tokumaru, H. Iwamoto, Y. Nishigaichi, I. Shiina
          Asian Journal of Organic Chemistry 2013, 2, 920–922. https://doi.org/10.1002/ajoc.201300139
          [Highlighted in ChemistryViews]

32.     Novel Tamoxifen Derivative Ridaifen-B Induces Bcl-2 Independent Autophagy without Estrogen Receptor
          Involvement
          Y. Nagahara, M. Takeyoshi, S. Sakemoto, I. Shiina, K. Nakata, K. Fujimori, Y. Wang, E. Umeda,
          C. Watanabe, S. Uetake, T. Yamori, S. Dan, Y. Yoshimi, T. Shiomiya, M. Ikekita
          Biochemical and Biophysical Research Communications 2013435, 657–663.

31.     Kinetic Resolution of Racemic 2-Hydroxy-γ-butyrolactones by Asymmetric Esterification Using
          Diphenylacetic Acid with Pivalic Anhydride and a Chiral Acyl-Transfer Catalyst
          K. Nakata, K. Gotoh, K. Ono, K. Futami, I. Shiina
          Organic Letters 201315, 1170–1173.

30.     Kinetic Resolution of Racemic Secondary Benzylic Alcohols by the Enantioselective Esterification of Using
          Pyridine-3-carboxylic Anhydride (3-PCA) with Chiral Acyl-Transfer Catalysts
          I. Shiina, K. Nakata, K. Ono, T. Mukaiyama
          Helvetica Chimica Acta 201295, 1891–1911.

29.     A New Method for Production of Chiral 2-Aryloxypropanoic Acids Using Effective Kinetic Resolution of
          Racemic 2-Aryloxycarboxylic Acids
          A. Tengeigi, K. Nakata, K. Ono, I. Shiina
          Heterocycles 201286, 1227–1252.

28.     Non-enzymatic Dynamic Kinetic Resolution of Racemic 
α-Arylalkanoic Acids: An Advanced Asymmetric
          Synthesis of 
Chiral Nonsteroidal Anti-inflammatory Drugs (NSAIDs)
          I. Shiina, K. Ono, K. Nakata
          Catalysis – Science & Technology 20122, 2200–2205.

27.     A Convenient Method for the Kinetic Resolution of Racemic 2-Hydroxyalkanoates Using Diphenylacetic
          Anhydride (DPHAA) and a Cchiral Acyl-Transfer Catalyst
          K. Nakata, A. Sekiguchi, I. Shiina
          Tetrahedron: Asymmetry 201122, 1610–1619.

26.     Synthesis of an Advanced Intermediate toward the hNK-1 Antagonist with the Cyclopentane Core
          K. Nakata, Y. Kiyotsuka, T. Kitazume, Y. Kobayashi
          Synlett 201119, 2872–2874.

25.     (
R)-(+)-N-Methylbenzoguanidine ((R)-NMBG) Catalyzed Kinetic Resolution of Racemic Secondary 
          Benzylic Alcohols with Free Carboxylic Acids by Asymmetric Esterification
          K. Nakata, I. Shiina
          Organic & Biomolecular Chemistry 20119, 7092–7096.

24.     Ridaifen-G Induced Caspase-independent Atypical Cell Death
          A. Anlifeire, M. Hatori, A. Morita, I. Shiina, K. Nakata, Y. Tosaki, Y.-W. Wang, M. Ikekita, G. Li
          Chinese Journal of Cell Biology 201133, 635–644.

23.     Kinetic Resolution of the Racemic 1-(Aryloxazol-2-yl)carbinols with Achiral Carboxylic Acids by Asymmetric
          Esterification: A New Method for the Preparing Chiral 1,2-Amino Alcohols
          K. Nakata, K. Ono, I. Shiina
          Heterocycles 201182, 1171–1180.

22.     Kintic Resolution of the Racemic 1-Heteroarylalkanols by the Asymmetric Esterification Using
          Diphenylacetic Acid with Pivalic Anhydride and a Chiral Acyl-Transfer Catalyst
          I. Shiina, K. Ono, K. Nakata 
          Chemistry Letters 201140, 147–149.

21.     Synthesis of Lasofoxifen, Nafoxidine and Their Positional Isomers via the Novel Three-Component
          Coupling Reaction
          K. Nakata, Y. Sano, I. Shiina
          Molecules 201015, 6773–6794.

20.     An Effective Kinetic Resolution of Racemic α-Arylpropanoic Acids, α-Arylbutanoic Acids, and
          β-Substituted-α-arylpropanoic Acids with Bis(9-phenanthryl)methanol as a New Achiral Nucleophile in the
          Asymmetric Esterification Using Carboxylic Anhydrides and the Acyl-transfer Catalyst
          K. Nakata, Y. Onda, K. Ono, I. Shiina
          Tetrahedron Letters 201051, 5666–5669.

19.     Kinetic Resolution of Racemic α-Arylalkanoic Acids with Achral Alcohols via the Asymmetric Esterification
          Using Carboxylic Anhydrides and Acyl-Tansfer Catalysts
          I. Shiina, K. Nakata, K. Ono, Y. Onda, M. Itagaki
          Journal of the American Chemical Society 2010132, 11629–11641.

18.     Kinetic Resolution of the Racemic 2-Hydroxyalkanoates Using the Enantioselective Mixed-Anhydride
          Method with Pivalic Anhydride and a Chiral Acyl-Transfer Catalyst
          I. Shiina, K. Nakata, K. Ono, M. Sugimoto, A. Sekiguchi
          Chemistry – A European Journal 201016, 167–172.

17.     An Effective Kinetic Resolution of Racemic Secondary Benzylic Alcohols Using 3-Pyridinecarboxylic
          Anhydride and a Chiral Acyl-Transfer Catalyst in the Absence of Tertiary Amine
          K. Nakata, I. Shiina
          Heterocycles 201080, 169–175.

16.     Allylic Substitution of 4-Cyclopentene-1,3-diol Monoacetate with Copper Reagents Derived from
          Functionalized Aryl Grignard Reagents
          Y. Kobayashi, Y. Tani, K. Nakata, Y. Kaneko
          Synlett 20102, 325–328.

15.     2,2-Disubstituted Propionic Anhydrides: Effective Coupling Reagents for the Kinetic Resolution of
          Secondary Benzylic Alcohols Using BTM
          I. Shiina, K. Nakata, M. Sugimoto, Y. Onda, T. Iizumi, K. Ono
          Heterocycles 200977, 801–810.

14.     Kinetic Resolution of Racemic Carboxylic Acids Using Achiral Alcohols by the Promotion of Benzoic 
          Anhydrides and Tetramisole Derivatives: An Application to Produce Chiral Nonsteroidal Anti-inflammatory
          Drugs and Their Esters
          I. Shiina, K. Nakata, Y. Onda
          European Journal of Organic Chemistry 2008, 5887–5890.

13.     Realization of 
Anti-SN2’ Selective Allylation of 4-Cyclopentene-1,3-diol Monoester with Aryl- and Alkenyl
          Zinc Reagents
          K. Nakata, Y. Kiyotsuka, T. Kitazume, Y. Kobayashi
          Organic Letters 200810, 1345–1348.

12.     Induction of Mitochondria-Involved Apoptosis in Estrogen Receptor Negative Cells by a Novel Tamoxifen
          Derivative, Ridaifen B
          Y. Nagahara, I. Shiina, K. Nakata, A. Sasaki, T. Miyamoto, M. Ikekita
          Cancer Science 200899, 608–614.

11.     Synthesis and Pharmacological Evaluation of the Novel 
pseudo-Symmetrical Tamoxifen Derivatives as
          Anti-tumor Agents
          I. Shiina, Y. Sano, K. Nakata, T. Kikuchi, A. Saski, M. Ikekita, Y. Nagahara, Y. Hasome, T. Yamori,
          K. Yamazaki
          Biochemical Pharmacology 200875, 1014–1026.

10.     4-(Dimethylamino)pyridine 
N-oxide (DMAPO): an Effective Nucleophilic Catalyst in the Peptide Coupling
          Reacion Using 2-Methyl-6-nitrobenzoic anhydride
          I. Shiina, H. Ushiyama, Y. Yamada, Y. Kawakita, K. Nakata
          Chemistry – An Asian Journal 20083, 454–461. 

9.     An Expeditious Synthesis of Tamoxifen, A Representative SERM (Selective Estrogen Receptor Modulator),
        via the Three-Component Coupling Reaction among Aromatic Aldehyde, Cinnamyltrimethylsilane and
        β-Chlorophenetole
        I. Shiina, Y. Sano, K. Nakata, M. Suzuki, T. Yokoyama, A. Sasaki, T. Orikasa, T. Miyamoto, M. Ikekita,
        Y. Nagahara, Y. Hasome
        Bioorganic & Medicinal Chemistry 200715, 7599–7617.

8.     The First Asymmetric Esterification of Free Carboxylic Acids with Racemic Alcohols Using Benzoic
        Anhydrides and Tetramisole Derivatives: An Application to the Kinetic Resolution of Secondary Benzylic
        Alcohols
        I. Shiina, K. Nakata
        Tetrahedron Letters 200748, 8314–8317.

7.     Synthesis of the New 
pseudo-Symmetrical Tamoxifen Derivatives and Their Anti-tumor Activity
        I. Shiina, Y. Sano, K. Nakata, T. Kikuchi, A. Sasaki, M. Ikekita, Y. Hasome
        Bioorganic & Medicinal Chemistry Letters 200717, 2421–2424.

6.     An Expeditious Synthesis of Lasofoxifene and Nafoxidine via the Novel Three-component Coupling
        Reaction
        Y. Sano, K. Nakata, T. Otoyama, S. Umeda, I. Shiina
        Chemistry Letters 200736, 40–41.

5.     Aryl- and Alkenyllithium Preparations and Copper-Catalyzed Reaction between the Derived Magnesium
        Reagents and the Monoacetate of 4-Cyclopentene-1,3-diol
        K. Nakata, Y. Kobayashi
        Organic Letters 20057, 1319–1322.

4.     New Reagent System for Attaining High Regio- and Stereoselectivities in Allylic Displacemet of
        4-Cyclopentene-1,3-diol Monoacetate with Aryl- and Alkenylmagnesium Bromide
        Y. Kobayashi, K. Nakata, T. Ainai
        Organic Letters 20052, 183–186.

3.  
  (Salen)ruthenium-Catalyzed Desymmetrization of Meso-Diols: Catalytic Aerobic Asymmetric Oxidation
        under Photo-Irradiation

        H. Shimizu, K. Nakata, T. Katsuki
        Chemistry Letters 2002, 1080–1081. 

2.     Synthesis and Reactivity of (1-Fluorovinyl)phenyl Sulfoxide as a Dienophile
        T. Hanamto, K. Korekoda, K. Nakata, K. Hamada, Y. Koga, M. Kondo
        Journal of Fluorine Chemistry 2002118, 99–101. 

1.     Asymmetric Epoxidation with a Photoactivated [Ru(salen)] Complex
        K. Nakata, T. Takeda, J. Mihara, T. Hamada, R. Irie, T. Katsuki
        Chemistry – A European Journal 20017, 3776–3782.


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