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  1. Kowaka E, Shimajiri Y, Kawakami K, Tongu M, Akama K (2015) Field trial of GABA-fortified rice plants and oral administration of milled rice in spontaneously hypertensive rats. Transgenic Research [Epub ahead of print]
  2. K. Kishimoto, Y. Shimajiri, A. Oshima, A. Hase, K. Mikami, K. Akama (2013) Functional expression of an animal type-Na+-ATPase gene from a marine red seaweed Porphyra yezoensis increases salinity tolerance in rice plants. Plant Biotech. 30:417-422.
  3. Y. Shimajiri, T. Oonishi, K. Ozaki, K. Kainou, K. Akama (2013) Genetic manipulation of the γ-aminobutyric acid (GABA) shunt in rice: overexpression of truncated glutamate decarboxylase (GAD2) and knockdown of γ-aminobutyric acid transaminase (GABA-T) lead to sustained and high levels of GABA accumulation in rice kernels. Plant Biotechnol J. 11:594-604, 2013.
  4. Y. Shimajiri, K. Ozaki, K. Kainou, K. Akama (2013) Differential subcellularlocalization, enzymatic properties and expression patterns of γ-aminobutyric acid transaminases (GABA-Ts) in rice (Oryza sativa). J Plant Physiol. 170:196-201.
  5. Y. Yukawa, K. Akama, K. Noguchi, M. Komiya, M. Sugiura (2013) The context of transcription start site regions is crucial for transcription of a plant tRNA(Lys)(UUU) gene group both in vitro and in vivo. Gene 512: 286-293.
  6. N. Mae, Y. Makino, S. Oshita, Y. Kawagoe, A. Tanaka, K. Aoki, A. Kurabayashi, T. Akihiro, K. Akama, S. Koike, M. Takayama, C. Matsukura, H. Ezura (2012) Accumulation mechanism of γ-aminobutyric acid in tomatoes (Solanum lycopersicum L.) under low O2 with and without CO2. J Agric Food Chem. 60:1013-9.
  7. N. Mae, Y. Makino, S. Oshita, Y. Kawagoe, A. Tanaka, T. Akihiro, K. Akama, S. Koike, C. Matsukura, H. Ezura (2010) Stimulation of γ-aminobutyric acid production in vine-ripened tomato (Solanum lycopersicum L.) fruits under an adjusted aerobic atmosphere, J Packaging Sci & Technol, Japan 19: 375-381.
  8. K. Akama, J. Kanetou, S. Shimosaki, K. Kawakami, S. Tsuchikura, and Fumio Takaiwa (2009) Seed-specific expression of truncated OsGAD2 produces GABA-enriched rice grains that influence a decrease in blood pressure in spontaneously hypertensive rats. Transgenic Res. 18: 865-876.
  9. T. Akihiro, S. Koike, R. Tani, T. Tominaga, S Watanabe, Y. Iijima, K. Aoki, D. Shibata, H. Ashihara, C. Matsukura, K. Akama and H. Ezura (2008) Biochemical mechanism on GABA accumulation during fruit development in tomato. Plant Cell Physiol., 49: 1378-1389.
  10. T. Akihiro, T. Fujimura, H. Ezura and K. Akama (2008) Olig microarray analysis of transcription in γ-aminobutyic acid-overaccumulating rice calli. Rice Genetics Newsletter, 24, 55-58.
  11. M. Englert, A. Latz, D. Becker, O. Gimple, H. Beier and K. Akama (2007) Plant pre-tRNA splicing enzymes are targeted to multiple cellular compartments. Biochemie, 89, 1351-1365.
  12. K. Akama and F. Takaiwa (2007) C-terminal extension of rice glutamate decarboxylase (OsGAD2) functions as an autoinhibitory domain and overexpression of a truncated mutant results in the accumulation of extremely high levels of GABA in plant cells. J. Exp. Bot, 58, 2699-2707.
  13. Y. Yukawa, T. Mizutani, K. Akama and M. Sugiura (2007) A survey of expressed tRNA genes in the chromosome I of Arabidopsis using an RNA polymerase III- dependent in vitro transcription system. GENE 392, 7-13.
  14. K. Akama and H. Beier (2003) Translational nonsense codon suppression as indicator for functional pre-tRNA splicing in transformed Arabidopsis hypocotyl-derived calli. Nucleic Acids Res., 31, 1197-1207.
  15. K. Akama, T. Akihiro, M. Kitagawa, F. Takaiwa (2001) Rice (Oryza sativa) contains a novel isoform of glutamate decarboxylase that lacks an authentic calmodulin-binding domain at the C-terminus. Biochim. Biophys. Acta, 1552, 143-150.
  16. Y. Yukawa, H. Fan, K. Akama, H. Beier and H.J. Gross and M. Sugiura (2001) A tobacco nuclear extract supporting transcription, processing, splicing and modification of plant intron-containing tRNA precursors. Plant J., 28, 583-594.
  17. K. Akama, V. Junker, and H. Beier (2000) Identification of two catalytic subunits of tRNA splicing endonuclease from Arabidopsis thaliana.GENE, 257, 177-185.
  18. K. Akama, V. Junker, Y. Yukawa, M. Sugiura and H. Beier (2000) Splicing of Arabidopsis tRNAMet precursors in tobacco cell and wheat germ extracts. Plant Mol. Biol., 44, 155-156.
  19. H. Kikuchi, S. Toki, S. Hirose, K. Akama and F. Takaiwa (1999) Molecular characterization of a gene for alanine aminotransferase from rice (Oryza sativa). Plant Mol. Biol., 39, 149-159.
  20. K. Akama, Y. Yukawa, M. Sugiura and I. Small (1998) Plant cytosolic tRNAHis possesses an exceptional C54 in the canonical TΨC loop. Nucleic Acids Res., 26, 2708-2714.
  21. K. Akama, V. Junker and H. Beier (1998) Characterization of a nuclear tRNACys gene from Arabidopsis thaliana. Plant Physiol.,116, 446.
  22. K. Akama, A. Nass, V. Junker and H. Beier (1997) Characterization of nuclear tRNATyr introns: their evolution from red algae to higher plants. FEBS Lett., 417, 213-218.
  23. R. Kumar, L. Marechal-Drouard, K. Akama, and I. Small (1996) Striking differences in mitochondria tRNA import between different plant species. Mol. Gen. Genet., 252, 404-411.
  24. K. Akama and M. Kashihara (1996) Plant nuclear tRNAMet genes are ubiquitously interrupted by introns. Plant Mol. Biol., 32, 427-434.
  25. K. Akama (1996) Molecular cloning and sequencing of a nuclear gene encoding tRNAGln (UUG) from Arabidopsis thaliana. Biochim. Biophys. Acta., 1307, 127-128.
  26. T. Ito, M. Hirano, K. Akama, Y. Shimura and K. Okada (1995) Touch-inducible genes for calmodulin and a calmodulin-related protein are located in tandem on a chromosome of Arabidopsis thaliana. Plant Cell Physiol., 36, 1369-1373.
  27. K. Akama, H. Puchta and B. Hohn (1995) Efficient Agrobacterium-mediated transformation of Arabidopsis thaliana using the bar gene as selectable marker. Pant Cell Rep., 14, 450-454.
  28. K. Akama, H. Shiraishi, S. Ohta, K. Nakamura, K. Okada and Y. Shimura (1992) Efficient transformation using hypocotyl explants of Arabidopsis thaliana: comparison of the efficiencies with various organs, plant ecotypes and Agrobacterium strains. Plant Cell Rep., 12, 7-11.
  29. K. Akama and S. Tanifuji (1990) Sequence analysis of three tRNAPhe nuclear genes and a mutated gene, and one gene for tRNAAla from Arabidopsis thaliana. Plant Mol. Biol., 15, 337-346.
  30. K. Akama and S. Tanifuji (1989) Nucleotide sequence of a putative pseudogene of histidine tRNA from Arabidopsis thaliana. Plant Mol. Biol., 13,721-722.
  31. K. Akama and S. Tanifuji (1989) Nucleotide sequence of a methionine initiator tRNA gene of Arabidopsis thaliana. Plant Mol. Biol., 13, 599-600.


  1. 二川健,越智ありさ,赤間一仁,他10名 (2011) 抗ユビキチン化ペプチドCblin (Cbl-b inhibitor) の高機能化.大豆たん白質研究, 14: 53-57.
  2. 赤間一仁 (2010) GABA強化米の開発、日本農薬学会誌35:157-159
  3. 赤間一仁 (2009) GABAを高濃度に含む健康機能性米,New Food Industry 51: 16-26.
  4. 赤間一仁,金藤純子,道田真帆子,下崎俊介,川上浩平 (2008)GABA強化米の開発と高血圧自然発症ラット (SHR) を用いた経口投与試験. アミノ酸研究,2(2): 143−146.
  5. 赤間一仁 (2005) RTS100小麦胚芽CECFキットを用いた3種類のイネカルモジュリンの機能解析. BIOCHEMICA,100:14-15.
  6. I. Small, K. Akama, K. Akashi, A. Chapron, N. Choisne, A. Dietrich, L. Drouard, A.M. Duchene, A. Giritch, D. Lancelin, N. Peeters, G. Souciet and Wintz (1999) taaRSAt, a database of tRNAs and aminoacyl-tRNA synthetases from Arabidopsis thaliana. Biochimie, 81, s341.
  7. K. Akama and H. Beier (1999) Molecular cloning and characterization of a nuclear gene encoding a putative subunit of tRNA splicing endonuclease from Arabidopsis thaliana. Nucleic Acids Sym. Series, 261-262.
  8. 村中俊哉, 赤間一仁, 岡田清孝, 町田泰則 (1992): 遺伝子導入実験法3-アグロバクテリウムを用いた形質転換- 植物細胞工学, 4巻3号193-203.